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Jan 21, 2017 · CLA is an effective weight loss supplement, but it may have harmful effects over the long term. The small amount of weight loss is not worth the risk. 11. Forskolin. WebMD looks at the safety and effectiveness of weight loss supplements like chitosan, chromium, conjugated linoleic acid (CLA), glucomannan, green tea extract, and more. Sep 18, 2020 · How Weight Loss Supplements Work 1. Appetite Suppression. Supplements for weight loss contain ingredients that can help reduce your appetite. Such that you get to eat less food and get full for longer. This will make you have lesser cravings for food. When you use weight loss supplements, they restrain you from feeling hungry to induce weight loss. The weight loss in the treatment group was modest, and the trial was only eight weeks, which isn't long enough to know if the supplement will help with weight loss long term. Plus, the supplement included multiple ingredients, making it impossible to judge which ingredients helped the weight loss.